Is there an association between Health Related Quality of Life, socio-demographic status and Fatigue in Patients with Chronic Hepatitis B?
| Journal | Volume 80 - 2017 |
| Issue | Fasc.2 - Original articles |
| Author(s) | M. Saffari, A. H. Pakpour, F. Al Zaben, H. G. Koenig |
| Full article |
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| (1) Health Research Center, Baqiyatallah University of Medical Sciences Tehran, Iran ; and, Health Education Department, School of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran ; (2) Social Determinants of Health Research Center, Qazvin University of Medical Sciences, Qazvin, Iran and Department of Nursing, School of Health and Welfare, Jönkoping University, Jönkoping, Sweden ; (3) Department of Psychiatry, King Abdulaziz University, Jeddah, Saudi Arabia ; (4) Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC USA, and Adjunct Professor, King Abdulaziz University, Jeddah, Saudi Arabia |
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Background : Chronic hepatitis B CHB) is a serious and preva- lent disease which may negatively influence health related qual- ity of life (HRQOL) and fatigue. The aim of the present study was to examine the relationship between demographic variables, HRQOL, and fatigue. Methods : A cross-sectional study was conducted involving 418 Iranian patients with CHB (average age 44.1 years, major- ity males). Participants completed a multidimensional fatigue inventory, chronic liver disease questionnaire, Euro quality of life-five dimensions questionnaire, and demographic information. Bivariate analyses were conducted using the Spearman correlation and Mann-Whitney U test. Hierarchical logistic regression model- ing identified independent predictors of fatigue. Results : The most prevalent problems related to HRQOL were anxiety/depression and pain/discomfort. Except for reduced moti- vation other dimensions of fatigue were significantly higher among those with CHB compared to healthy controls (p<0.05). Age, sex, education, employment, disease stage and all HRQOL subscales were significantly related to fatigue level. The Nagelkerke R Square for the logistic regression model was 0.542. Conclusions: Poor HRQOL and fatigue are widespread among patients with CHB. Given these associations between demographic, psychological, and other HRQOL dimensions and fatigue, inter- ventions that address these factors may help to reduce fatigue in patients with CHB. (Acta gastroenterol. belg., 2017, 80, 229-236). |
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© Acta Gastro-Enterologica Belgica. PMID 29560687 |
